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GLP-1 peptides, FDA-approved for type-2 diabetes (e.g., Semaglutide and Exenatide) and weight loss (Semaglutide) have been studied for their effects on alcohol use in both preclinical and clinical studies (for a detailed review: 10)

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In addition, knockdown of AMPK with short hairpin AMPK RNA abolished the liraglutide activation of AMPK and anti-inflammatory effects