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Retatrutide at the 12 mg dose with 24.2% over 48 weeks (TRIUMPH-1, NEJM 2023), followed by tirzepatide at 15 mg with 20.9% over 72 weeks (SURMOUNT-1), then semaglutide at 2.4 mg with 14.9% over 68 weeks (STEP-1)

If you are prescribed any weight-loss medicine and experience a suspected side effect, please report it via the MHRA Yellow Card Scheme (yellowcard.mhra.gov.uk)

KPV peptide is an alpha-MSH derivative with potent anti-inflammatory properties that works through NF-kB inhibition, the same pathway affected by GLP-1 agonists