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It should be injected under the skin in the thigh, abdomen, or upper arm

Integrin-dependent force transmission to the extracellular matrix by alpha-actinin triggers adhesion maturation

Our findings, in a group of relatively well-controlled individuals with diabetes, not only reinforce the need for additional retinal photography in those already at high risk of PDR who commence treatment with tirzepatide but also provide reassurance that EWDR is rare in individuals with lower pre-treatment risk

AADs also play a critical role in acute, life-threatening events such as electrical storm (10)

Offering patients the benefits of a GLP-1 receptor agonist in a once-daily tablet could overcome some of the obstacles that lead to therapeutic inertia, as evidence suggests that patient concerns over potential side effects of therapies, including hypoglycaemia and weight gain, as well as fear of injections, often lead to delayed intensification of treatment, despite poor glycaemic control [12, 46,47,48]