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Notably, like other cholesterol biosynthesis inhibitors, triparanol activated transcription of cholesterol biosynthetic genes SQLE and FDFT1 , indicating a functional consequence of DHCR24 inhibition (Supplementary Fig

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[38] Lilly MB, Wu C, Ke Y, et al

Body weight was recorded at baseline and on days 5, 8 and 15 and the treatment dose was adjusted based on recent body weights recorded during the treatment period (Fig 2) Using the same study protocol, data involving the CON group has been previously published [10]