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Combined use should always follow clinical assessment and should not replace investigation of underlying causes

Reciprocally, gut microbiota biotransform dietary components to produce various physiologically active metabolites, such as SCFAs, secondary bile acids, and indole derivatives, which enter the liver via the portal venous system and participate in host glucose and lipid metabolism as well as immune regulation ( The concept of the gut-liver-kidney nutritional metabolic axis has gradually emerged and received widespread attention in recent years

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10.1021/acs.est.3c00593 40 DongY.WangH.LiX.SunS.WenS.YingL.et al (2025)

This involves: Reversed amino acid sequence Use of D-amino acids instead of natural L-amino acids Potential advantages include: Increased stability Improved resistance to enzymatic degradation Extended biological activity Enhanced peptide durability in research models Potential Research Areas of FOXO4-DRI 1