Instead of changes on the scale, early signs may include: Feeling less hungry between meals Thinking about food less often Feeling satisfied with smaller portions These cues typically suggest that the medication is starting to take effect, even if visible weight loss has not yet appeared
Nutrients (2019) 11(1):157
The ensuing negative feedback loop may involve not only EECs but also Paneth cells and intestinal intraepithelial lymphocytes, as these cells have been reported to express the receptor for GLP-1 (namely GLP-1R), and loss of GLP-1R increases the severity of DSS-induced intestinal injury8, 9
In addition, the adoption of continuous glucose monitoring systems (CGMS) has risen significantly in the past few years [64, 65]
To this end, the amylin and glucagon-like peptide-1 (GLP-1) hormonal systems have been independently identified as promising targets for pharmacotherapy intervention 6,7,8,9,10,11