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Increasing faster than every four weeks significantly raises the risk of severe nausea and vomiting

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These state signals may alter subjective hedonic evaluation (liking) and motivational drive (wanting) without necessarily affecting basic gustatory discrimination

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Accordingly, incretin-based therapies, such as DPP-4 inhibitors and GLP-1 receptor agonists (GLP-1 RAs) that are resistant to degradation by DPP-4, have been introduced in the market within the past decade to overcome and extend the short half-life of the incretin effect