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However, some individuals may experience persistent nausea or develop constipation as gastric emptying remains slowed

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The drugs work by mimicking GLP-1, a hormone the gut releases after eating that stimulates insulin release and suppresses glucagon to control blood sugar

More common side effects of Zepbound are digestive side effects, such as: nausea and vomiting abdominal pain diarrhea indigestion (upset stomach) constipation If you have questions about side effects of Zepbound, talk with your doctor or pharmacist

Studies have shown that retatrutide maintains common interactions with conserved residues across the three receptors while also accommodating receptor-specific interactions that enhance its binding affinity and efficacy