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Drugs like tirzepatide and semaglutide have demonstrated promising clinical outcomes in many patients

Side effects Common side effects Nausea Diarrhea Vomiting Constipation Abdominal pain Headache Fatigue Injection site reactions Other potential side effects: Indigestion Dizziness Back pain Increased lipase or amylase Altered taste Nasopharyngitis (common cold) Passing gas Bloating Belching Gastroenteritis Decreased appetite Gastroesophageal reflux disease Upset stomach These symptoms often subside as your body adjusts to the medications

For researchers considering other alternatives alongside this transition, understanding how retatrutide compares to survodutide , CagriSema , orforglipron , and mazdutide provides the full landscape of next-generation options

The medications most commonly associated with B12 deficiencies include metformin (diabetes), antacids, anti-ulcers, blood pressure, cholesterol meds, and birth control pills (12, 13)

Data published in the journal Obesity shows that slightly more than 50% of patients stop using semaglutide or tirzepatide for obesity treatment within a year