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Retatrutide sits at the intersection of these forces: a potential blockbuster that will test both payers' capacity to absorb new costs and manufacturers' ability to maintain pricing discipline as the IRA's reach expands

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For Medicare Part D, this model will be implemented in January 2027, following a separate short-term demonstration that will allow Medicare Part D enrollees to access obesity drugs beginning in July 2026

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Once they do find a legal, licensed compounding facility, there are still unresolved questions about where compounders are sourcing their active ingredients, whether anyone is safety-testing those products, and whether they are manufacturing them in a sterile environment