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Even assuming the composition patents expire on schedule, the manufacturing scale-up, ANDA preparation, FDA review, and commercial distribution infrastructure build-out suggests 3-5 years from patent expiry before meaningful market share for any single biosimilar semaglutide product

doi:10.1074/jbc.M809338200, PMID: 19176520 Suthanthiran M, Anderson ME, Sharma VK, Meister A (1990) Glutathione regulates activation-dependent DNA synthesis in highly purified normal human T lymphocytes stimulated via the CD2 and CD3 antigens

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HM15211 is another triagonist compound which has shown favourable pre-clinical data in animal models of steatohepatitis [61,62,63] and which is currently in phase 1 trials