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However, the use of conventional anticancer agents has been highly limited due to the random tissue-distribution of cytotoxic anticancer drugs following systemic administration, which can cause non-specific toxicity to the normal tissues

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In terms of efficacy, GH and IGF-1 both stimulated linear growth but some variables including the greater growth deficit in infants with Laron syndrome than those with isolated growth hormone deficiency, insufficient IGF-1 dose, or the IGF-1 dependency on the GH-linked stem cell population of prechondrocytes made GH more efficient in terms of linear growth stimulation (170, 171)