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35 However, treatment satisfaction, including perceived efficacy, was not assessed and so the effect on the discontinuation rate remains unclear

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Women of childbearing potential should be aware that tirzepatide may reduce the effectiveness of oral hormonal contraceptives, particularly after initiation or dose increases, and should consider using non-oral or additional contraceptive methods

Beginner protocol Those new to IGF-1 LR3 should start conservatively to assess individual response and tolerance

Statistical analyses Pharmacokinetic and statistical analyses were performed using GraphPad Prism Version 9