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Examples: A Truveris analysis of over 1.1 million GLP-1 claims from early 2023 to early 2025 found that GLP-1 spend increased fivefold, with a 16% average cost increase per claim, highlighting the need for utilization strategies such as step therapy, targeted prior authorization, and indication-based coverage

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In 2012 the method to test the difference between distributions across years was changed to use a Wald test which accounts for the complex survey design

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doi: 10.1016/j.chroma.2023.463936 98 LiZWuQZhangXChenG