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As a ghrelin mimetic, ipamorelin binds to ghrelin receptors in the pituitary gland and stimulates the release of an intermediary hormone, growth hormone stimulating hormone

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276 Another study in more than 17,000 postmenopausal women not using hormone therapy found those who lost at least 10 pounds or 10% of their baseline body weight after one year were more likely to report resolution of their hot flashes than those whose weight was unchanged