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In the landmark FLOW clinical trial published in the New England Journal of Medicine, Semaglutide (Ozempic) reduced the risk of clinically important kidney outcomes and death from cardiovascular causes in patients with type 2 diabetes and chronic kidney disease

it remains preliminary and awaits larger confirmation

Our results are consistent with a post hoc analysis of the EXCEL trial [29] which concluded that exenatide combined with SGLT-2i reduced the risk of MACE (defined as cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke) compared with exenatide monotherapy and also improved eGFR significantly

Semaglutide Injection is $189/mo month-to-month (or $149/mo on the 6-month plan) with flat pricing across all dose levels and commitment tiers, and treatments are HSA/FSA eligible

Supplies of both Wegovy and Zepbound remain constrained, but the companies have been increasing production