In comparison to the placebo group, T2DM subjects post-3 months supplementation with L-GSH had a significant several-fold increase in the production of both IFN- ( Figures 6B, C ) and TNF- ( Figures 6D, E ) in the granuloma supernatants from the L-GSH group at both 8-days and 15- days post in vitro BCG infection
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GSH is capable of scavenging ROS through Nrf2-mediated heme oxygenase-1 induction and enhancing M1-like macrophage polarization regulation, showing that GSH may be a useful strategy to increase the human defense system (Mittal et al., 2014
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