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For context, traditional lifestyle interventions typically result in a 2-5% weight loss

On the contrary, a systematic review on mortality, as well as cardiovascular and kidney statuses in patients with T2DM treated with GLP-1RAs concluded that there was no increase in the incidence of severe hypoglycaemia, pancreatitis, or pancreatic cancer (222)

Buyer Takeaway: The regulatory outcome is uncertain as of June 2026 but is likely to restrict large-scale compounded GLP-1 availability

Ferreira JP, Sharma A, Butler J, Packer M, Zannad F, Vasques-Nvoa F et al (2023) Glucagon-like peptide-1 receptor agonists across the spectrum of heart failure

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