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Semaglutide, a synthetic GLP-1 analog, features a 31-amino-acid sequence modified with a C18 fatty diacid at Lys26 via a -glutamyl and [2-(2-aminoethoxy)ethoxy]acetic acid (AEEAc) spacer

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Clinical trials show its superior A1C reduction compared to Trulicity, Januvia, and dose-adjusted Lantus

Both T2DM and CVD share common risk factors, such as obesity, hypertension, and dyslipidemia, which further enhances the codependent relationship between both conditions [71]