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This means intrinsic factor, as well as other factors required for B 12 absorption, are not available

Some studies have shown that, if people with Down syndrome take the inactive oral forms of vitamin B12 and folate, their bodies may have difficulty converting from the inactive to the active form and the inactive form may not be as effective

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Repeated freeze-thaw cycles should be strictly limited to no more than three, as each cycle promotes peptide bond hydrolysis and aggregation that progressively reduces recoverable bioactive peptide content