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Bitter melon extracts and some other herbal preparations have shown promising GLP1like effects in animals and small human studies

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Electrophysiological recordings further supported this, revealing that Dihexa caused a 1.6-fold increase and Nle-AngIV caused a 1.7-fold increase in the frequency of AMPA-mediated mEPSCs compared to vehicle-treated neurons, indicating an expansion of functional synapses without altering individual synapse properties such as amplitude, rise, or decay times

Retatrutide is an unlicensed investigational triple incretin receptor agonist by Eli Lilly