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Thats because peptides degrade easily in the digestive tract and tend to be too large molecularly to permeate the skin or intestinal lining,5 often yielding a bioavailability as low as 1-2%.6 But there are some peptides that have a small enough molecular size that they easily transfer into the bloodstream as either an oral or a topical supplement

sciencedirect.com Pharmacokinetics: early studies (including dog PK) explore exposure at microgram-scale dosing

This breaks the tripeptide into glutamate, cysteine, and glycine before absorption

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