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7A), synapses with narrow synaptic clefts and sharply defined, electron-dense postsynaptic densities (PSDs), and presynaptic terminals containing abundant synaptic vesicles (SVs) clustered near active zones (Fig

Common symptoms of MTHFR gene mutation, or MTHF indicators, include: Chronic fatigue Miscarriage or multiple miscarriages Histamine intolerance Increased risk of cancer Hormone imbalance Cardiovascular and thromboembolic diseases, specifically blood clots, stroke, embolism, and heart attacks Depression, anxiety, bipolar disorder or schizophrenia Colon cancer Acute leukemia Chronic pain Oestrogen dominant conditions such as fibrocystic breasts, fibrocystic ovaries, heavy periods, uterine fibroids, endometriosis, and severe premenstrual syndrome Allergies, asthma, hives Migraines ADD or ADHD Learning difficulties at school / you may find it hard to concentrate Elevated liver enzymes Elevated red cell folate Chronic constipation or diarrhoea Low vitamin B12 levels Dizziness Elevated homocysteine levels 2 MTHFR variants can also lead to serious genetic disorders such as homocystinuria, anencephaly and spina bifida