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In a 2022 Cochrane review, etanercept twice weekly until healing was the only treatment that reached low-certainty evidence, possibly offering a superior mortality benefit to corticosteroids [130]

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This multifactorial etiology supports the view of ALS as a point of no return disease, where the failure of therapies to halt disease progression reflects the deep complexity of its biology [59, 60]

Diabet Med 2004;21:13461352 [DOI] [PubMed] [Google Scholar] 7.Bravi MC, Armiento A, Laurenti O, Cassone-Faldetta M, De Luca O, Moretti A, De Mattia G: Insulin decreases intracellular oxidative stress in patients with type 2 diabetes mellitus