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The analysis included 173,846 patients (86,923 per cohort) after propensity score matching for demographic, metabolic, and systemic covariates.The researchers found that compared with the lifestyle intervention alone cohort, tirzepatide use was associated with a reduced 12-month risk for DR incidence and worsening events, including incident mild nonproliferative DR, proliferative DR, DR with macular edema, vitreous hemorrhage, tractional retinal detachment, intravitreal antivascular endothelial growth factor injection, and pan-retinal photocoagulation (risk ratios, 0.864, 0.705, 0.624, 0.607, 0.370, 0.479, and 0.610, respectively)."Our study and others suggest that medications like semaglutide and tirzepatide may not affect diabetic retinopathy in the same way," Shah said in a statement

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It significantly decreased levels of malondialdehyde (MDA), a marker of oxidative damage, while downregulating the expression of transient receptor potential vanilloid 1 (TRPV1), NF-B, COX-2, and the pro-apoptotic protein Bax

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