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Yes, significant weight loss can alter hormone levels as adipose tissue produces and metabolises hormones like oestrogen

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The results of the trial were published in The Lancet on May 2, 2026

3 Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

Quality assessment Six studies were classified as having a high risk of performance bias and one was categorized as having a unclear risk of performance bias