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(1978) [1] reported that the alpha -aspartyl form of position 5 is biologically active in the delta-EEG rabbit assay, while the beta-aspartyl isomer showed substantially reduced activity

It was found that when the amide or carboxyl groups are substituted for the cyano group, the inhibitory activity decreases significantly

Oxidative stress is controlled very tightly in the thyroid gland via the synthesis of glutathione peroxidase, which can safely inactivate sources of oxidative stress, such as hydrogen peroxide and free radicals