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The disadvantage is that higher doses require large injection volumes

J Inherit Metab Dis 29(23):383389

In people with T2D, the incretin effect is severely attenuated, despite similar levels of circulating GLP-1

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Horses were given the following three treatment diets: control (without supplementation), MSM 8 mg/kg, and combined supplements (MSM 8 mg/kg + Vit-C 5 mg/kg)