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Review of high-risk factors Previous studies have shown that the development of DILI depends not only on the offending drug but also on host-related risk factors, including advanced age, female sex, pre-existing or concomitant liver disease, metabolic syndrome and diabetes, heavy alcohol use, polypharmacy, and genetic susceptibility mediated by specific HLA alleles (47)

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Pathol 8(24):672684 Ellison DA, Adada B, Qualman SJ, Parham DM (2007) Melanotic neuroectodermal tumor of infancy: report of a case with myogenic differentiation

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