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In each sample, to assess the DSB signal in 4,6-diamidino-2-phenylindole (DAPI) + positive cells, we used two different measures: the fraction of cells positive for DSBs over the total number of cells, calculated as the number of cells positive for H2AX over the total number of DAPI + cells, and the median intensity of the fluorescent signal for H2AX + cells

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