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The possible mechanisms that account for the beneficial response seen with L-carnitine in AMI are probably multifactorial and include, in part, an improvement in myocardial mitochondrial energy metabolism in the heart due to its ability to enhance the transport of long-chain fatty acids from the cytosol to the mitochondrial matrix where -oxidation occurs, removing toxic fatty acid intermediates, lessening ischemia secondary to elevated long-chain fatty acid concentrations, and replenishing the depleted carnitine concentrations seen in ischemic, infarct, and failing myocardium
The most common included: Injection-site irritation or redness Water retention and swelling Elevated blood pressure Headaches or dizziness Digestive discomfort such as diarrhoea During Phase II clinical trials, three subjects experienced heart attacks after CJC-1295 administration (Teichman et al., 2005)
