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Peak plasma concentrations occur 13 days post-injection, with half-lives ranging 714 days depending on the specific compound and formulation

Several probes have been developed, such as octreoscan and depreotide, as radiolabeled conjugates of somatostatin-like peptides, have been approved by the FDA for imaging of tumors, such as neuroendocrine tumors and lung cancer 385,386

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In contrast, in 2018, the long-acting GIPGLP-1 co-agonist tirzepatide was found to have substantial glucose-lowering and weight loss properties, to a greater extent than that achieved by GLP-1R agonism with dulaglutide [68], findings replicated in Phase III trials comparing tirzepatide with semaglutide in people with type 2 diabetes [69]

[PubMed] [Google Scholar] Zhang H, Court N, Forman HJ