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The new indication formalizes a clinical use case Kelly has performed for years with strong off-label evidence behind it

The single biggest lever is the price per prescription, because the long-term bill is mostly volume multiplied by a high unit price that has not come down much. Before this work, the surge in these prescriptions was easy to see in headlines but hard to size at the national level, and easy to mistake for a cost borne mainly by the people taking them

A review of 14 scientific papers examining the application of the principles of antimicrobial stewardship in community-acquired pneumonia found an increase in appropriate antimicrobial use and a reduction in unnecessary antimicrobial prescribing

But there was one problem

As we have discussed, the thyroid produces 93% T4 and then the T4 travels into the liver for conversion to T3 and reverse T3