In the pivotal WILLOW Phase II trial, brensocatib significantly extended time to first exacerbation (hazard ratio 0.580.62, p 90%), with relatively smaller inhibitory effects on PR3 activity (approximately 53%60%)
Thus, following the identification of active BAT in adult humans and the demonstration that certain depots of white adipose tissue can undergo browning, there has been recent interest in the development of approaches that induce BAT activity and promote browning [10]
Their widespread use for diabetes, obesity, and cardiometabolic health has naturally drawn attention far beyond their original indications
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Protein band intensities were quantified using ImageJ software (version 1.60)