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The glucagon component increases energy expenditure, meaning you burn more calories even at rest

Studies following patients over 3+ years demonstrate that those who maintain consistent dosing keep more weight off and experience better metabolic improvements in blood sugar control and cardiovascular markers

In particular, it appears in some instances that GLP1 signalling in the arcuate nucleus and/or proopiomelanocortin neurons may alter energy balance/glucose metabolism, whereas at other times, this may not occur

doi: 10.1007/s12011-011-9174-y 31 KobayashiYOgraYIshiwataKTakayamaHAimiNSuzukiKT