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Treatments The group 1-treatment with the TRX2 supplement supplied, via three hard shell capsules, per day: 544 mg L-carnitine, 150 mg L-leucine, 100 mg potassium, 75 mg L-isoleucine, 75 mg L-valine, 40 mg nicotinamide, 15 mg zinc, 150 g biotin, and 75 g selenium

Holocarboxylase Synthetase Deficiency (Multiple Carboxylase Deficiency) Holocarboxylase synthetase is the enzyme that attaches biotin to the biotin-dependent carboxylases, acetyl-CoA carboxylase (ACC), propionyl-CoA carboxylase (PCC), pyruvate carboxylase (PC), and 3-methylcrotonyl-CoA carboxylase (3MCC)