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A bioluminescent-based probe for in vivo non-invasive monitoring of nicotinamide riboside uptake reveals a link between metastasis and NAD+ metabolism

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These irreversible thiol modifications can lead to protein degradation and loss of function and are present in neurodegenerative diseases (Ren et al., 2017)

The limitation of this study is that it only tested one dose and did not compare it with positive controls given anti-depressants