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Notably, there exists crosstalk between FXR and TGR5, and FXR activation induce TGR5 gene transcription, thereby promoting glucagon-like peptide-1 (GLP-1) secretion from intestinal L cells (77, 78)

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Additional research highlights its influence on the gut-brain axis , with reported effects on intestinal barrier function and mucosal regeneration

All samples were serially diluted in assay buffer in duplicate and incubated with cells for 30 min at RT before detection with the cAMP dynamic 2 HTRF assay (Cisbio assays, Bedford, MA) as described previously 51

Pernicious anemia often occurs parallel to other autoimmune disorders [27] and in people who are first-degree relatives of patients with this condition [58]