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Lipid peroxidation products including malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE) form adducts with cellular proteins, generating neo-epitopes that activate immune cells and enhance antigen presentation (101)

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[12] The glutathione molecule binds in a cleft between N - and C -terminal domains - the catalytically important residues are proposed to reside in the N -terminal domain