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And patients want to access these medications at an affordable price point. Many insurers are narrowing eligibility for GLP-1 coverage to high-risk patientstypically those with Type 2 diabetes, or with a BMI over a certain threshold and a weight-related comorbidity (e.g., hypertension, sleep apnea)

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Aberrant secretion of interleukins (e.g., IL-1, IL-6) and TNF- may impair ovulatory cascade signaling, while elevated prostaglandins and dysregulated angiogenesis can interfere with follicle rupture and luteal function