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There is no UK Summary of Product Characteristics (SmPC) for retatrutide, and no authorised clinical dosing or reconstitution guidance exists

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In a rat model of intervertebral disc degeneration, MOTS-c injection preserved disc height (82.4% versus 58.7% in the untreated group), restored MRI signals indicating improved disc hydration, and reduced histological degeneration scores by 44% compared to untreated controls

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