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Secreted form of GLP-1 is GLP-1 (137), which is susceptible to amidation and proteolytic cleavage resulting in two equipotent biologically active forms GLP-1 (736) and GLP-1 (737)

[12] Beyond that specific episode, GH secretagogues generally can affect glucose metabolism and insulin sensitivity: raising GH tends to oppose insulin action, and studies of oral ghrelin-mimetic secretagogues in older adults have documented measurable effects on glucose handling alongside their GH and IGF-I elevation

Although the possibility of a peroxidase-based reaction had been noted, ascorbate was proposed to be oxidized by O 2 as part of a respiratory chain, possibly linked to ascorbate oxidase (Fig