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102 (11): 22612268.e2

Specifically, chronic inflammatory signals stimulate fibroblasts to induce the structural hardening of tissues, and the stiffened extracellular matrix (ECM) stimulates immune cells to fix inflammation (Parker et al

Based on the clinical trial data and the known mechanism, AOD 9604 does not appear to cause muscle loss

Once tumor cells reach distant metastatic sites, ZFP281 maintains tumor dormancy and prevents tumor proliferation over extended periods via the induction of the class IIcadherin 11