Potential adverse effects of resveratrol: A literature review
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1 Introduction Prostate cancer (PCa) is the fifth leading cause of cancer-related mortality in men worldwide, as well as being the second most commonly diagnosed solid-organ cancer, after lung cancer, in men ( 2 The insulin-like growth factor family The mammalian insulin-like growth factor (IGF) family is made up of three ligands (IGF-I, IGF-II, and insulin) and three receptors (IGF-I receptor (IGF-1R), insulin receptor (IR), and IGF-II receptor (IGF-2R)) ( 2.1 IGFs In mammalian cells, the production of IGF-I is mainly induced by growth hormones and transcriptional factors
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The result: increased mitochondrial DNA quantity, enhanced cellular respiration, and elevated activities of key enzymes including citrate synthase and cytochrome c oxidase
