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Rare side effects include gastroparesis which can cause paralysis, usually temporary, but has resulted in 1800 lawsuits in the US as of May 2025

Here are some of the main culprits behind low glutathione: Chronic Stress: Constant stress elevates cortisol levels aka the stress hormone. While cortisol helps manage stress, excessive amounts increase oxidative stress, leading to glutathione depletion as it works to protect cells from damage

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However, a significant challenge in evaluating kidney outcomes lies in the inconsistent definitions of renal endpoints across studies, particularly regarding the thresholds for substantial eGFR decline, which vary from 30% to 57%