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doi:10.26355/eurrev_201801_14128

Many report reduced pain and increased mobility within the first week

Far in the lead is Lilly with its late-stage orforglipron, which in a June 2023 Phase II readout achieved weight loss between 9.4% and 14.7% at 36 weeks

In some embodiments, the otoprotectant is a compound comprising a urea-thiophene-carboxamide moiety of Formula (IV): wherein X is a heteroatom that includes N, 0, or S