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Ageing Res Rev (2017) 40:3144

Meta-analyses indicate that high blood pressure is associated with an elevated risk of AD and vascular dementia (VAD), while coronary artery disease (CAD) and heart failure (HF) are linked to accelerated cognitive decline, particularly affecting memory, executive function, and processing speed

This helps to protect patients from unnecessary exposure to drugs that have not been shown to be safe and effective, and that offer fewer assurances of manufacturing quality

No significant association was observed between treatment with any OMM and the risk for either suicide attempt or depression, except for naltrexone plus bupropion, which was associated with a significantly lower risk of depression (Table 1)

This highlights the need for long-term treatment