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Improvements in 5-HT production occur by increasing EC expression of tryptophan hydroxylase, the rate-limiting enzyme in EC 5-HT production 288 , or by increasing microbial metabolites, such as SCFAs and BAs, that are known to stimulate EC 5-HT production 74

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The primary objective of FLOW was to demonstrate that Ozempic delays the progression of renal impairment and lowers the risk of renal and cardiovascular mortality compared to placebo, both added to standard-of-care, in subjects with type 2 diabetes and chronic kidney disease

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