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Prolonged daily dosing beyond 12 weeks transitions naturally into maintenance protocols using 23 doses weekly, which thousands of users sustain year-round without reported tolerance or receptor desensitization

Zhuang et al., 2019)

(PubMed) Lawson LD, Wang ZJ, Papadimitriou D

But if you combine regular, moderate alcohol use with repeated daily doses of acetaminophen, it can make your liver more susceptible to a condition called acetaminophen toxicity