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If GHK-Cu penetrates poorly through intact skin, the observed clinical effects could be occurring primarily at the epidermal level rather than reaching dermal fibroblasts where collagen synthesis occurs

Hcy levels were reduced 25 % by creatine, and increased 50 % with GAA, while plasma methionine levels were unchanged

( 10.2337/dc13-2760) [DOI] [PubMed] [Google Scholar] 101.Buse JB, Nauck M, Forst T, Sheu WHH, Shenouda SK, Heilmann CR, Hoogwerf BJ, Gao A, Boardman MK, Fineman Met al